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33 Liver transplantation may be considered in patients with end-stage liver disease, HCC, or in those who are not responsive to medical therapies

While the efficacy of PARP inhibitors has been evaluated in several studies in pancreatic cancer, there are hardly any reported in CCA and data from two first-line umbrella studies using veliparib (NCT01282333) and rucaparib (NCT03337087) in combination with chemotherapy are awaited

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Its bias is heavily skewed toward neuroprotection and the stabilization of the brain environment